Recent publications

  1. TCA Cycle and Mitochondrial Membrane Potential Are Necessary for Diverse Biological Functions. Martínez-Reyes I, Diebold LP, Kong H, Schieber M, Huang H, Hensley CT, Mehta MM, Wang T, Santos JH, Woychik R, Dufour E, Spelbrink JN, Weinberg SE, Zhao Y, DeBerardinis RJ, Chandel NS. Mol Cell. 2016 Jan 21;61(2):199-209.

  2. Human Mitochondrial DNA-Protein Complexes Attach to a Cholesterol-Rich Membrane Structure. Gerhold JM, Cansiz-Arda Ş, Lõhmus M, Engberg O, Reyes A, van Rennes H, Sanz A, Holt IJ, Cooper HM, Spelbrink JN.  Sci Rep. 2015 Oct 19;5:15292.

  3. The hexameric structure of the human mitochondrial replicative helicase Twinkle. Fernández-Millán P, Lázaro M, Cansız-Arda Ş, Gerhold JM, Rajala N, Schmitz CA, Silva-Espiña C, Gil D, Bernadó P, Valle M, Spelbrink JN, Solà M. Nucleic Acids Res. 2015 Apr 30;43(8):4284-95.

  4. Whole cell formaldehyde cross-linking simplifies purification of mitochondrial nucleoids and associated proteins involved in mitochondrial gene expression. Rajala N, Hensen F, Wessels HJ, Ives D, Gloerich J, Spelbrink JN. PLoS One. 2015 Feb 19;10(2):e0116726.

  5. Replication factors transiently associate with mtDNA at the mitochondrial inner membrane to facilitate replication. Rajala N, Gerhold JM, Martinsson P, Klymov A, Spelbrink JN. Nucleic Acids Res. 2014 Jan;42(2):952-67

  6. Functional organization of mammalian mitochondrial DNA in nucleoids: history, recent developments, and future challenges. Spelbrink JN. IUBMB Life. 2010 Jan;62(1):19-32

  7. The human SIRT3 protein deacetylase is exclusively mitochondrial. Cooper HM, Spelbrink JN. Biochem J. 2008 Apr 15;411(2):279-85

  8. Expression of catalytic mutants of the mtDNA helicase Twinkle and polymerase POLG causes distinct replication stalling phenotypes. Wanrooij S, Goffart S, Pohjoismäki JL, Yasukawa T, Spelbrink JN. Nucleic Acids Res. 2007;35(10):3238-51

  9. Human mitochondrial DNA deletions associated with mutations in the gene encoding Twinkle, a phage T7 gene 4-like proteinlocalized in mitochondria. Spelbrink JN, Li FY, Tiranti V, Nikali K, Yuan QP, Tariq M, Wanrooij S, Garrido N, Comi G, Morandi L, Santoro L, Toscano A, Fabrizi GM, Somer H, Croxen R, Beeson D, Poulton J, Suomalainen A, Jacobs HT, Zeviani M, Larsson C. Nat Genet. 2001 Jul;28(3):223-31

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