Clinical aspects of mitochondrial disorders

Saskia Koene

Clinical research coordinator: Dr Saskia Koene

The common goal of the members of the clinical research team is to make substantial contributions to the well being of the patients we care for. As such, members of the team are involved in improving awareness for mitochondrial disease, optimizing diagnostics, developing diagnostic guidelines, long term follow up of patient cohorts, developing and validating clinically relevant outcome measures as well as prognostic scores and biomarkers, the evaluation of commonly used medications and anesthesia in relation to mitochondrial function, and drug development and clinical intervention studies. Beside the projects focusing on patients with mitochondrial disease, we are exploring the modifying role of mitochondrial dysfunction in the relationship between inactivity and chronic disease and in the consequences of certain predispositions, life styles and environmental factors on the risk of developing diseases later in life. The clinical aspects theme consists of eight highly interactive subthemes with strong bounds with both the structure-function and the cellular consequences themes as well as national and international mitochondrial clinical expertcenters.

Clinical Aspects: research groups

Chris Verhaak 2

 Psychological Aspects of  Mitochondrial Diseases  

 Dr. Chris Verhaak

Imelda de Groot

 Pediatric Rehabilitation

 Dr. Imelda de Groot 

Maria Hopman

 Physiology

 Prof. Maria Hopman

Saskia Koene

 Outcome Measures

 Dr. Saskia Koene

Cees Tack

 Diabetes                

 Prof. Cees Tack

Frans Russel  

 Drug efficacy and safety 

 Prof. Frans Russel

Jan Smeitink 2

Causes, consequences and intervention 

 Prof. Jan Smeitink

Mirian Janssen

Patient cohorts  and Clinical Trials

 Dr. Mirian Janssen