Clinical aspects of mitochondrial disorders

Coordinator: Prof Jan Smeitink

The common goal of the members of the clinical research team is to make substantial contributions to the well being of patients we care for. As such members of the team are involved in improving awareness for mitochondrial disease, optimizing diagnostics, developing diagnostic guidelines, long term follow up of patient cohorts, developing and validating clinical relevant outcome measures as well as prognostic scores and biomarkers, the evaluation of commonly used medications and anesthesia in relation to mitochondrial function, and drug development and clinical intervention studies. The clinical aspects theme consists of eight highly interactive subthemes with strong bounds with both the structure-function and the cellular consequences themes as well as national and international mitochondrial clinical centers. 

Clinical aspects

Cees Tack


Prof. Cees Tack

 Frans Russel

Drug efficacy and safety 

Prof. Frans Russel

Jan Smeitink 2

Preclinical Drug Development  

Prof. Jan Smeitink

 Mirian Janssen

Clinical Trials

Dr. Mirian Janssen

 Mirian Janssen

Patient Cohorts

Dr. Mirian Janssen

   Outcome measures
  • Prof. Maria Hopman
  • Dr. Imelda de Groot
  • Dr. Chris Verhaak
  • Dr. Mirian Janssen